Title: Clinical analyses of 20 newborn cases with congenital adrenal hyperplasia
Abstract: Objective To investigate clinical features,diagnosis and treatment of neonatal congenital adrenal hyperplasia(CAH).Methods All cases of neonatal CAH admitted to the neonatal center in Beijing Children's Hospital from February 2002 to June 2009 were included for this study.The clinical manifestations,serum test results and adrenal ultrasound of each case are summarized to diagnose and sub-type to evaluate the hormone treatment and prognosis.Results Among the 20 cases of CAH,11 cases were sub-typed as 21-hydroxylase deficiency salt-losing form,and 9 cases as simple virilizing form.10 cases of CAH have been presented as adrenal crises.After treatment,19 cases showed clinical improvement and were discharged;one case refused treatment after diagnosis.There were 10 cases under follow-up,and 10 cases lost contact with the center.With the follow-up cases,three cases have been exacerbated by infection and re-hospitalized;three cases have maintained by a small amount of hormone treatment without exacerbations after the infection.Two cases ceased hormone treatment and are growing and developing normally in addition to having dark skin.The remaining 2 cases deceased.Conclusion The most common form of CAH in neonatal period is caused by 21-hydroxylase deficiency that is prone to adrenal crisis.Corticosteroid therapy is an effective treatment but whether some patients must continue life-long hormone treatment is worth further research.
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
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