Title: Preliminary study of hybrid bioartifidal liver in patients with severe hepatitis and hepatic failure
Abstract: Objective To observe the clinical effects and safety of hybrid bioartificial liver (HBL)in patients with severe hepatitis.Methods 20 patients suffering from severe hepatitis were treated with hybrid bioartificial Liver (HBL) consisting of PE(plasma exchange) HP(hemoperfusion) XRRT and porcine hepatocyte - based bioartificial respectively.Other 20 cases with similar condition were compared as control.All of them were under standard therapeutic procedure.Results The 20 patients undergiong the treatment of HBL showed significant inprovements in clinical signs and symptoms,total serum bilirubin( TBIL); endotoxin,prothrombin activity (PAT) and ammonia.After the treatment,5 patients were discharged for spontaneous recovery and 10 for improvement,1 patient bridged for liver transplantation,another 2 patients recovered and the other 2 patients died or get worse.The control group 4 patients were discharged for spontaneous recovery and 2 for improvement,2 patients died.The survival rate is 75% and 35% in the control group.(P 0.01) The effective rate in HBL gronp is 90% .Conclusion HBL can be a safe and beneficial treatment for patients with severe hepatitis and hepatic failure.HBL was well tolerated with evidence of clinical improvement and mild side effects.
Publication Year: 2002
Publication Date: 2002-01-01
Language: en
Type: article
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