Title: FDG uptake in PET imaging correlates with DNA ploidity in non small cell lung carcinoma
Abstract: Objective DNA ploidity analysis of resected tumor tissue to grade the malignancy is of prognostic value for patients with non-small cell lung cancer (NSCLC). 18F-fluorodeoxyglucose (FDG) imaging has been proven useful for tumor staging. In this study, we evaluated whether 18F-FDG uptake within the primary lesion correlates with DNA ploidity of tumors in patients with NSCLC. Methods Forty-nine patients with histologically proven NSCLC underwent whole-body FDG PET 45~90 min after i.v. injection of 6 MBq/kg body weight of 18F-FDG prior to surgery, and the primary tumor FDG uptake on PET images was quantified with the standardized uptake value(SUV) and metabolic tumor diameter(MTD). The DNA content and DNA-malignancy grading (DNA-MG) of Schiff-stained nuclei obtained from fresh tumor fragments taken from these patients during the surgery were evaluated by means of image cytometry. The correlation between SUV and MTD and between SUV and 2c deviation index (2cDI) or between SUV and DNA-MG were analyzed using linear fit. Results The primary tumors as well as metastatic lymph nodes of the total 49 patients were well present on PET images, so that the result data of SUV and MTD were demonstrated satisfactorily. Of the DNA histograms of these 49 patients, 46(93.88%) were aneuploid and only 3(6.12%) were tetraploid. A linear correlation of the SUV versus the MTD (r=0.632, P0.01)) and versus the 2cDI or DNA-MG (r=0.363, P0.05; r=0.336, P0.05) were found. Conclusions Metabolic consumption of FDG is a better indicator of viable tumor cells which avidly take up FDG and whole body FDG PET has already proven its cost-effectiveness in diagnosis in lung cancer patients. Whereas the DNA distribution patterns characterized by the existence aneuploid cells and increased mean DNA content have appeared to be an indicator of malignancy and to have an independent prognostic value. Our data demonstrate that 18F-FDG PET as a non-invasive metabolic imaging technique, may also provide correlated information between SUV and DNA contents, 2cDI or DNA-MG, which may be valuable in malignancy differentiation and prognostic prediction.
Publication Year: 2002
Publication Date: 2002-01-01
Language: en
Type: article
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