Title: Effect of Purendan Ultrafine Powder on the Expression of Vascular Endothelial Growth Factor in Retina of Diabetic Rats
Abstract:OBJECTIVE:To study the effect of Purendan ultrafine powder on the expression of vascular endothelial growth factor(VEGF) in retina of diabetic rats by observing the protein expression of retina of rat...OBJECTIVE:To study the effect of Purendan ultrafine powder on the expression of vascular endothelial growth factor(VEGF) in retina of diabetic rats by observing the protein expression of retina of rats.METHODS:Diabetic rat models were established by intraperitoneal injection of streptozotocin(STZ).The experimental rats were divided into normal group,model group and Purendan ultrafine powder group,and were killed in 5 months to study the expression of VGEF.The level of blood glucose in rats were determined after 1,3,5,months of ig administration.RESULTS:Negative results were obtained in normal group,weakly positive results were obtained in Purendan ultrafine powder group,and strongly positive results were obtained in model group.There were significant difference among those groups(P0.01).After 5 months ig administration,the level of blood glucose in model group increased significantly,compared with normal group.The level of blood glucose in Purendan ultrafine powder group decreased significantly,compared with model group(P0.01).CONCLUSION:Purendan ultrafine powder may relieve or treat diabetic retinopathy by actively suppressing the expression of VEGF and decreasing the level of blood glucose in retina of diabetic rats.Read More
Publication Year: 2011
Publication Date: 2011-01-01
Language: en
Type: article
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