Title: The prevention and efficacy for early hepatic injury after renal transplantation
Abstract: Objective To investigate the preventive measure and therapeutic efficacy for the early hepatic injury induced by renal transplantation. Methods Five-hundred and four patients after renal transplantation were ramdomly divided into two groups. The routine prevention group (n=251) were received with glutathione 2 400 mg intravenously together with conventional medicine after renal transplantation. Non-prevention group (n=253) were not given any liver-protective agent in addition to routine medication. If the hepatic injury still appeared after conventional prevention,patients were randomly divided into two groups according to the different treatment options. Group A with 34 patients was received with bicyclol orally 75 mg daily for 8 weeks and group B with 34 patients was administrated with Tiopronin tablets 600 mg/d also for 8 weeks. Results The incidence of liver injury in routine prevention group is significantly lower than that of non-prevention group (P0.01); for the patients with liver injury after routine prevention,additional treatment with bicyclol exhibited a clearly superior role in improving liver function and comprehensive therapeutic effect to Tiopronin (P0.05,P0.01). No obvious drug-related adverse events were found. Conclusion Glutathione can prevent early stage liver injury after renal transplantation. Combined therapy with bicyclol and glutathione can efficiently improve liver injury when routine prevention was invalid.
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
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