Title: Observation of the effect and safety of high doses of captopril in treatment of congestive heart failure associated with hypotension
Abstract: [Objective] To evaluate the effect and safety of high doses of captopril in treatment of congestive heart failure associated with hypotension.[Methods] 46 cases of congestive heart failure associated with hypotension(90-80/70-60 mmHg) were randomly assigned and then treated with either low doses(56.25 mg/d,group A) or high doses of captopril(165.65 mg/d,group B) after basic heart failure treatment for 2 weeks.Before and 20 weeks after treatment,NYHA classifications,6-minute walk test,echocardiography,blood pressure,heart rates and blood biochemistry indexes were detected.[Results] During 20 weeks' follow-up,3 patients(2 in group A,1 in group B) died,among them 1 due to sudden death,and 2 due to aggravated heart failure.After therapy,NYHA classifications,6-minute walk distances were improved significantly in both groups,which were more significant in group B than those in group A.The changes of left ventricular end-diastolic diameter,left ventricular end-systolic diameter and left ventricular eject fraction in group B were greater than those in group A.Compared with pretherapy,heart rates decreased remarkably in both groups,but there were no statistical differences between the 2 groups.Serum concentrations of creatinine increased significantly in group B compared with pretherapy,although in normal ranges.There were no statistical differences in other serum biochemistry indexes pre and post therapy in both groups.[Conclusion] High doses of captopril are safe in treatment of congestive heart failure associated with hypotension,and have a favorable effect on left ventricular function.
Publication Year: 2007
Publication Date: 2007-01-01
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot