Title: Synthesis and Characterization of 3,3,3-Trimethoxypropanenitrile
Abstract: 3,3,3-Trimethoxypropanenitrile was synthesized after two-step reactions by using malononitrile as raw material.Through the analysis of gas chromatography,the product purity reached 98.08%.GC-MS,IR and 1HNMR were applied to the product characterization.The optimum reaction conditions of the first step to synthesize methyl cyanoacetimidate hydrochloride were determined as follows:water content of solvent less than 100×10-6,ventilation time of 3 h,malononitrile amount of 72 g,methanol amount of 45 mL,ether amount of 1440 mL,stirring for 7 h at room temperature.The optimum reaction conditions of the second step to synthesize 3,3,3-trimethoxypropanenitrile were as follows:the ratio of methyl cyanoacetimidate hydrochloride to methanol of 1 g∶7.35 mL,stirring time of 24 h,removing ammonia chloride after reacted for 10 h,using anhydrous sodium choloride as drying agent.
Publication Year: 2012
Publication Date: 2012-01-01
Language: en
Type: article
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