Title: Effects of morphine on systemic inflammatory response and oxygenation in patients underwent one lung ventilation
Abstract: Objective To observe the effects of morphine on systemic inflammatory response and oxygenation in patients underwent one lung ventilation (OLV).Methods Thirty patients undergoing thoracic surgery under OLV were randomly divided into normal saline group and morphine(M) group with 15 cases each. Blood samples of arterial and jugular vein were taken 1 min before OLV( T1 ),at 3 min after completion of OLV (T2 ),and 30 min after T2 (T3 ) for blood gas analysis and detecting serum levels of neutrophil,superoxide dismutase(SOD),malondialdehyde(MDA),intercellular adhesion molecule-1(ICAM-1),tumor necrosis factor-α(TNF-α) and plasma endothelin-1(ET-1 ). Results Intrapulmonary shunt (Qs/Qt) increased and oxygen index (OI) decreased at T2 and T3 compared to those at T1 in both groups.Qs/Qt was lower and OI was higher at T3 in group M than those in group C.Compared to those at T1 ,serum neutrophil was higher at T2 and T3 (P 0.05) in both groups.Serum SOD was lower,MDA,ICAM-1 and TNF-α were higher,at T2 and T3 in group C than those at T1 (P 0.05).Serum SOD was higher and ICAM-1 and TNF-α were lower at T3 than those at T1 in group M.Serum MDA and plasma ET-1 were lower at T2 and T3 than those at T1 in group M (P 0.05).Serum SOD was higher and ICAM-1 and MDA were lower in group M than those in group C at T3 (P 0.05).Serum TNF-α and plasma ET-1 were lower in group M than those in group C at T2 and T3 (P 0.05).Conclusion Morphine has protective effects on systemic inflammatory response and oxygenation in patients underwent OLV.
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
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