Title: Effects of prenatal exposure to low level lead on hippocampal GFAP expression of rats' offspring
Abstract:Objective To observe the effects of prenatal exposure to low level lead on the protein and mRNA expression of glial fibrillary acidic protein(GFAP)in hippocampus of rat's offspring,and to explore the ...Objective To observe the effects of prenatal exposure to low level lead on the protein and mRNA expression of glial fibrillary acidic protein(GFAP)in hippocampus of rat's offspring,and to explore the molecular mechanisms of lead on learning and memory.Methods The pregnant rats were randomizedly divided into 4 groups and provided with doubly evaporated water in control groups and 125,250,500 mg/L lead acetate solution via drinking water in treatment groups respectively during pregnancy.The GFAP protein and mRNA expression at hippocampal CA1 region were observed by immunohistochemistry and in situ hybridization.Results The cell numbers of GFAP protein and mRNA positive expression at 1-day and 21-day old offsprings in treatment group were significantly higher than that of control(P0.05),but no significant difference at 60-day old offsprings.Conclusion Prenatal exposure to low level lead could promote the GFAP protein and mRNA expression at hippocampal CA1 region,which maybe is one of the molecular mechanisms of lead on learning and memory.Read More
Publication Year: 2007
Publication Date: 2007-01-01
Language: en
Type: article
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