Title: Expression and significance of Laminin-R,Paxllin and CD105 in human breast cancer:high throughput tissue microarray analysis
Abstract: OBJECTIVE:The objective of this study was to determine the expression of Laminin-R,Paxillin and CD105 in breast carcinomas using a tissue microarray(TMA),and investigate their clinical and prognostic valuation.METHODS:We analyzed Laminin-R,Paxillin,CD105,ER and PR expression in 160 samples of breast invasive ductal carcinomas immunohistochemically by TMA technology.Results were correlated with various clinic-pathological variables.RESULTS:The expression of Laminin-R in breast cancer was 55.6%(89/160).The expression of LN-R was related to lymphnode metastasis(P0.05),but not to pathologic grade,ER positive or PR positive.The expression rate of Paxllin in these samples is 31.88%(51/160),and was related to pathologic grade(P0.05),but not to lymphnode metastasis,ER positive or PR positive.CD105 expression(measured by microvessel density)was not related to pathologic grade,lymph node metastasis,ER positive or PR positive.CONCLUSIONS:The TMA technology makes the detection of the prognosis-associated indexes of breast cancer easily and quickly.These results suggest that both Laminin-R and Paxllin expression are associated with the biological behavior of human breast cancer,may be helpful to estimate the prognosis of breast carcinoma.
Publication Year: 2009
Publication Date: 2009-01-01
Language: en
Type: article
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