Title: Three Dimensional MRI of Male Schizophrenia Patients and the Relationship Between Their Symptoms and Brain Structure
Abstract: Objective:To explore the pathological mechanism of brain structure in schizophrenia male patients with predominant negative symptoms by Voxel-based Morphometry(VBM) and Wiconsin Card Sorting test(WCST).Methods:Schizophrenia patients were assessed by the Scale for Assessment of Positive Symptoms(SAPS),the Scale for Assessment of Negative Symptoms(SANS).Finally,fifteen male schizophrenia with predominant negative symptoms and fifteen matched healthy controls participated in the study and finished the Wisconsin Card Sorting Test(WCST) and 3D MRI scans.Results:The total trails,the number of response errors and perseverant response errors of WCST in the patient group were significantly higher than those in the control group(P0.05).However,there were no significant differences in the number of correct responses and the number of categories between the two groups.In addition,schizophrenia patients showed significantly lower gray matter density than healthy controls in the right superior frontal gyrus,left middle frontal gyrus,left medial frontal gyrus,right cuneus,and left middle temporal gyrus.There was no area showing higher gray matter density in the patient group compared with the control group.Conclusion:Compared with the healthy controls,schizophrenic patients with predominant negative symptoms show significant frontal executive function impairments.The reduction of gray-matter-density in the bilateral frontal regions is probably the pathophysiological basis for the cognitive impairment in negative subtype schizophrenia patients.
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
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Cited By Count: 1
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