Title: Advances in VEGF Receptor Tyrosine Kinase Inhibitors
Abstract: Angiogenesis is a fundamental process of tumor growth and metastasis, and thus inhibition of angiogenesis induced by tumors has become an important trend in research and development of novel antineoplastic drugs. The vascular endothelial growth factor (VEGF), known as the most potent and specific angiogenetic factor, represents an key target for the discovery of anti angiogenesis inhibitors. Receptor tyrosine kinase (RTK) inhibitors targeting VEGF receptor is one of the most promising agents. Recent developments of these inhibitors were reviewed, and their structure activity relationship was discussed.
Publication Year: 2002
Publication Date: 2002-01-01
Language: en
Type: article
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