Title: IMMUNOHISTOCHEMICAL STUDY ON MYOEPITHELIUM CELLS IN BREAST CARCINOMA
Abstract: The expression of S-100 protein (S-100) and carcinoembryonal antigen (CEA)in myoepithelium cells of 50 breast carcinoma and 20 benign lesion of breast were studied using PAP method (some cases using Immuno-Gold, -silver double staining). The results indicatd:1. Myoepithelium cells proliferated in varying degrees in all benign lesions of breast, showed S-100 positivity. However, there was no any S-100 positive cells in breast carcinoma nest and cells around tubular structure. So, we believe that the proliferation or disappearance of myoepithelium cells has significance for differentiating the benign and malignamt lesion of breast. 2. 23 among 50 (46%).breast carcinoma patients expressed S-100 protein in varying degrees. 3. The Z-100 positive cells showed nuclear atypia in HE stained slides. It was thought that myoepithelium cells participated in the neoplastic transformation. 4. CEA was expressed in 45/50 cases (90%), and S-100 was positive in 23/50 cases. We agree with the hypothesis that breast carcinoma originated from the stem cells with two-way bifferentiation potential.
Publication Year: 1992
Publication Date: 1992-01-01
Language: en
Type: article
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