Title: Experimental study of synovium gene expression profile of collagen induced arthritis(CIA)rats by cDNA microarrays
Abstract:Objective To study synovitis gene expression profile of CIA rats and then to explore the mechnism of rheumatoid arthritis (RA) pathogenesis. Methods cDNA microarray chips containing 588 rat target gen...Objective To study synovitis gene expression profile of CIA rats and then to explore the mechnism of rheumatoid arthritis (RA) pathogenesis. Methods cDNA microarray chips containing 588 rat target genes were used to identify gene expression profile in synovitis of CIA rats and normal rats. Results Among the target genes, 68 differentially expressed genes were identified in CIA rats. Sixty-three genes were up-regulated and 5 genes were down-regulated. Conclusion CIA is an immunogenic disorder with many abnomal expression genes. Genes screened from the target can provide important information for futher study and treatment of RA.Read More
Publication Year: 2005
Publication Date: 2005-01-01
Language: en
Type: article
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