Title: Protective effect of lycopene on renal damage caused by chlorinated mercury in rats
Abstract: Objective To investigate protective effect of lycopene on renal damage induced by chlorinated mercury.Methods The rats were treated with 40 mg/kg lycopene by gavage and subcutaneously injected with 8.8 μmol/kg chlorinated mercury once a day for two days.The contents of glutathione(GSH),malonodialdehyde(MDA),superoxide dismutase(SOD),glutathione peroxidase(GSH-Px) in renal cortical,blood urea nitrogen(BUN),urinary protein,alkaline phosphatase(ALP),β-N-acetyl-glucosaminidase(NAG),lactate dehydrogenase(LDH),and Hg in urine were determined.Results In comparison with the high-dose chlorinated mercury group,nephrotoxicity in the group of lycopene pretreatment was reversed.The activities of NAG(103.73±21.79),LDH(113.19±23.74)and ALP(73.64±21.51 U/gcr) decreased significantly in urine of the rats.The content of the urinary protein decreased to 4.40±1.12 g/g Cr.and the content of GSH and MDA decreased to 45.33±5.90 and 1.03±0.12 μmol/g pro.The activity of the SOD and GSH-Px increased to 39.94±6.04 and 85.62±12.68 U/mg pro in rats kidney.In addition,BUN in serum dropped to 15.93±9.36 mmol/L.All of differences were statistically significant(P0.05 forall).Conclusion Lycopene have protective effect on Hg-induced toxicity.
Publication Year: 2011
Publication Date: 2011-01-01
Language: en
Type: article
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