Title: Mechanism of ren shen qiang xin di wan for rats with congestive heart failure
Abstract: [Objective] To investigate the effect of ren shen qiang xin di wan on cardiac muscle cell apoptosis and the related controlling genes of rats with congestive heart failure(CHF),and elucidate the therapeutic mechanism of ren shen qiang xin di wan on CHF. [Methods] The animal model of CHF was made by the method of abdominal aorta coarctation.Rats were randomly divided into sham group,CHF group,high doses of ren shen qiang xin di wan group,low dose of ren shen qiang xin di wan group,and positive control group(xin bao wan).Rat cardiac muscle cell apoptosis and the expression of apoptosis-related protein Bax and Bcl-2 were observed by flow cytometry.[Results] The rate of cardiocyte apoptosis was significantly increased in the rats with CHF.The expression of Bax was increased while the Bcl-2 expression was decreased in the cardiocytes from rats with CHF.Whereas in the three therapeutic groups with ren shen qiang xin di wan or xin bao wan,cardiocytes apoptosis rats were decreased significantly.Bax expression was decreased and Bcl-2 expression was increased.[Conclusion] Ren shen qiang xin di wan can reverse cardiac ventricle remodeling and improve the prognosis of heart failure by regulating the expression of Bax and Bcl-2,and reducing the rate of cardiocyte apoptosis.
Publication Year: 2006
Publication Date: 2006-01-01
Language: en
Type: article
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