Title: Expression of Ki-67 and its Significance in Barrett's Esophagus,Severe Reflux Esophagitis and Esophageal Adenocarcinoma
Abstract:Background: Barrett's esophagus is a precancerous lesion of esophageal adenocarcinoma. Ki-67 is an antigen which can be used to estimate the process of cell proliferation and may play an important rol...Background: Barrett's esophagus is a precancerous lesion of esophageal adenocarcinoma. Ki-67 is an antigen which can be used to estimate the process of cell proliferation and may play an important role in the course of development of cancer. Aims: To investigate the expression of Ki-67 and its significance in Barrett's esophagus, severe reflux esophagitis and esophageal adenocarcinoma. Methods: Expression of Ki-67 was determined in 59 cases of Barrett's esophagus, 5 severe reflux esophagitis, 5 esophageal adenocarcinoma, and 10 normal esophageal epithelium by immunohistochemical staining (SP method). Results: Expression of Ki-67 was positive in 80.0% of severe reflux esophagitis and 76.3% of Barrett's esophagus, significantly higher than that in normal esophageal epithelium (20.0%, P0.05). In esophageal adenocarcinoma, the expression of Ki-67 was positive in 100% of cases. The expression of Ki-67 increased with increase of the degree of intestinal metaplasia in Barrett's esophagus (P0.05), however, its expression was not significantly different between different length (short-segment and long-segment), types of Barrett's esophagus (circumferential, tongue and island types) and different degrees of dysplasia (low or moderate degree) (P0.05). Conclusions: Expression of Ki-67 increases in severe reflux esophagitis and Barrett's esophagus, and may play an important role in the course of development of esophageal adenocarcinoma.Read More
Publication Year: 2007
Publication Date: 2007-01-01
Language: en
Type: article
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