Title: Detection of gadolinium concentration in simulated cerebral spinal fluid on fluid-attenuated inversion recovery sequence at low field MR imaging unit:an in vitro investigation
Abstract: Objective To evaluate the ability of T2-weighted fluid-attenuated inversion recovery(FLAIR)MR images to detect gadolinium concentrations in artificial cerebral spinal fluid(CSF)in an in vitro study at low field MRI.Methods Different enhancement in CSF was simulated with mixtures of artificial CSF and gadolinium chelate ranging from 0 mmol/L to 8 mmol/L.Fresh hard-boiled egg white was used to simulate normal cerebral parenchyma.T2-weighted turbo-FLAIR and T1-weighted spin-echo (SE)MR imaging of these phantoms was performed on a 0.35-T MR system.The contrast-to-noise ratios(CNRs)between the different gadolinium chelate artificial CSF mixture and hard-boiled egg white were measured and compared on both images.Results The gadolinium concentration that can be detected on T2-weighted FLAIR image was 0.0078 retooL/L,which was ten-fold lower than that on T1-weighted SE image.T2-weighted FLAIR image was not as effective as T1-weighted SE image in revealing gadolinium when its concentration was over 0.8 mmol/L.Conclusion T2-weighted FLAIR imaging is obviously superior to T1-weighted SE imaging in demonstrating low concentrations of gadolinium in artificial CSF in a low-field MR system.
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
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