Title: Nicotine inhibit the recruitment of CD8 lymphocytes produced by 6-hydroxydopamine lesion in the striatum of SD rat
Abstract: Objective: To explore the mechanism through which nicotine protects dopaminergic neurons against 6-OHDA toxicity in SD rat PD model. Methods: Rats received nicotine or saline treatment (two doses tested,0.2 mg/ kg and 2 mg/ kg, 5 injections i.p. per day at 2-h intervals). 8 days after the treatment, a single injection of 20μg 6-OHDA was administered into striatum. Nicotine or saline was administered daily until animals were sacrificed. The dopaminergic neurons and CD8-positive lymphocytes were analyzed quantitatively using immunohistochemistry and stereology. Results: The loss of dopaminergic neurons induced by 6-OHDA in the substantia nigra was significantly less severe in the nicotine treatment groups (at both 0.2 and 2 mg/kg groups) than in the saline treated group(P0.01). In addition, the number of CD8-positive lymphocytes reduced significantly in the nicotine treated animals as compared to saline control(P0.05).Conclusion: Our data suggest that nicotine may have a neuroprotective effect against 6-OHDA induced dopaminergic lesion by inhibiting the recruitment of CD8-positive lymphocytes.
Publication Year: 2007
Publication Date: 2007-01-01
Language: en
Type: article
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