Title: Experimental study of esophagus reconstruction with biological artificial esophagus in dogs
Abstract:Objective Currently, little material is available for esophagus reconstruction and the survival rate within perioperative period is low in animal experiments in the literature. This study assesses the...Objective Currently, little material is available for esophagus reconstruction and the survival rate within perioperative period is low in animal experiments in the literature. This study assesses the feasibility of esophagus reconstruction with biological artificial esophagus in dogs. Methods The biological artificial esophagus and 30 Chinese mongrels were used as experimental materials. Part of the thoracic esophagus of dogs were resected, then 8 cm length biological artificial esophagus were implanted to reconstruct the esophagus. The surviving and eating, as well as healing process were observed. Results Among the 30 dogs, 28 dogs were survived after perioperative period,the survival rate was 93.3%. The anastomotic leakage was found in 2 dogs(6.67%). Nineteen dogs were survived for one year, and the survival rate was 79.2%(19/24, 6 dogs were killed according to the experimental protocol). The average time of exfoliation of biological artificial esophagus was 28.8 days. The dysphagia was occurred 23 to 45 days, and 2 months after operation, however, it can be remitted by itself after 4 months. The histology showed that the regenerated esophagus was consisted of fibrous and connective tissue, and the luminal surface of regenerated esophagus was coverd with squamous epithelium within 3-6 months. Conclusions The “new esophagus” was regenerated after the operation of esophagus reconstruction, and the biological artificial esophagus would exfoliate. While the regenerated esophagus mould, the stenosis was relieved by itself. To solve the exfoliation of artificial esophagus and stenosis after operation is the key for the biological artificial esophagus to be used in clinics.Read More
Publication Year: 2003
Publication Date: 2003-01-01
Language: en
Type: article
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Cited By Count: 1
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