Title: Relationship Between Expression of ESM-1 and MMP-3 and Invasion and Metastasis of Human Hepatocellular Carcinoma
Abstract: Objective To explore the relationship between expression of ESM-1 and MMP-3 and invasion and metastasis of human hepatocellular carcinoma(HCC).Methods The expression levels of ESM-1 and MMP-3 in 40 specimens with HCC(test group) and 15 specimens of liver tissue of intrahepatic bile duct stone(control group) were detected by immunohistochemistry and an image-analysis system.The relativity between the expression of ESM-1 and MMP-3 and clinicopathologic features and the correlation between the expression of ESM-1 and MMP-3 were analysed.Results ESM-1,MMP-3were expressed at high level in all 40 specimens,but not expressed in liver tissues of 15 specimens with intrahepatic bile duct stone.There was significant difference of expression of ESM-1 and MMP-3 between test group and control group(P 0.05).The expression of ESM-1 in HCC tissues was positively correlated with the level of preoperative serum alpha-fetoprotein(AFP),cirrhosis,tumor size,the histological differentiation,venous invasion and TNM stage(P 0.05 ).The expression of MMP-3 was positively correlated with the HBV infection,tumor size,venous invasion,histological differentiation and TNM stage(P 0.05).The mean gray scale of ESM-1 was positively correlated with that of MMP- 3(r=0.641,P0.05).Conclusions ESM-1 and MMP-3 may be used as the new useful predictors of invasion and metastasis in patients with HCC.
Publication Year: 2012
Publication Date: 2012-01-01
Language: en
Type: article
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Cited By Count: 2
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