Title: Effect of Metoprolol on cardiac function and hypertensive left ventricular hypertrophy
Abstract: OBJECTIVE:To study the effect of Metoprolol on cardiac function and hypertensive left ventricular hypertrophy.METHOD:Sixty one patients with hypertensive left ventricular hypertrophy were randomly divided into 2 groups, 31 in treatment group and 30 in control group. The patients in treatment group were given 25~50mg Metoprolol once or twice a day and the patients in control group were given 1 piece compound hypotensive once for three times a day, which should be used for 12 to 16 weeks with average of 13.2 weeks until blood pressure was controlled at or near critical level. Under color Doppler flow image, ventricular hypertrophy and cardiac function were compared before and after treatment with statistic method. RESULTS:It showed that HR, SBP, DBP and TPR were dropped down with total effective rate of 87% (P0.01). Left ventricular morphosis criterion as LAD, LVD and LVMI were all obviously improved ( P 0.05~0.01). Left ventricular diastolic function criterion as A,E, A/E, PER and NPFR were also improved ( P 0.05). No changes occurred in left ventricular systolic criterion as SV, EF and CO ( P 0.05).CONCLUSIONS:Metoprolol can treat hypertension as well as improve cardiac diastolic function and left ventricular hypertrophy.
Publication Year: 2002
Publication Date: 2002-01-01
Language: en
Type: article
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