Title: A prospective randomized study on effect of durations of antithyroid drug on relapse cured in patients with Graves disease
Abstract: Objective To compare the effect of different duration of antithyroid durg(ATD)on the remission rate.In order to investigate the optimal regimen of ATD therapy on the Graves disease.Methods 192 patients were divided randomly into three groups (group 1 for 12 months,group Ⅲ for 24 months,group Ⅲ for 36 months).All patients received carbimazole 30mg daily for 2~3months,following it reduced doses of maintain after 6 months and plus L T4 50 μg daily for treatment duration of in three groups.To observe relapse rate after ATD treatment within the provide of two years in groups each.Results The relapse rate were 69%,38.2 %,and 21.2% within the provide of two years in groups each respectively.There was significant difference in three groups( P 0.01).Levels of TSAb also significant difference in groups Ⅰand groups Ⅱ,Ⅲ,but did not differ between the groupsⅡand Ⅲ.Conclusion prolonging ATD treatment significantly improves the remission rate in GD.The optimal duration of treatment for Graves disease is 3 years.
Publication Year: 2003
Publication Date: 2003-01-01
Language: en
Type: article
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