Title: Determination of serum cystatin C in chronic kidney disease
Abstract: Objective To study the correlation between serum cystatin C and serum creatinine,glomerular filtration rate and creatinine clearance rate in chronic kidney disease.Methods Glomerular filtration rate was estimated by the clearance of 99mTc-DTPA.Serum cystatin C was measured by particle-enhanced turbidimetric immunoassay.According to glomerular filtration rate,75 patients with chronic kidney disease were divided into three groups,group A(glomerular filtration rate≥60 mL/(min·1.73 m2),n=21),group B(30 mL/(min·1.73 m2)≤glomerular filtration rate60 mL/(min·1.73 m2),n=27) and group C(glomerular filtration rate30 mL/(min·1.73 m2,n=27)).Serum creatinine and blood urea nitrogen were detected in each group.Creatinine clearance rate was calculated by formula CG and MDRD.The correlation of serum cystatin C with glomerular filtration rate and creatinine clearance rate were studied in each group.Results In group B and C,serum cystatin C was positively correlated to blood urea nitrogen and serum creatinine,and negatively correlated to glomerular filtration rate,creatinine clearance rate and creatinine clearance rate.Serum cystatin C was not correlated to the above indices in group A(P0.05).Serum cystatin C increased and serum creatinine kept normal in 6 cases(28.57%) in group A and 14 cases(51.86%) in group B.Conclusion Serum cystatin C increases with the decrease of glomerular filtration rate and creatinine clearance rate in chronic kidney disease,which occurs earlier than the increase of serum creatinine.The detection of serum cystatin C is especially important for patients with the third stage of chronic kidney disease and normal serum creatinine level.
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
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