Publication Information

{'id': 'https://openalex.org/W2358324654', 'doi': None, 'title': 'Inhibition of oridonin in HepG-2 cells proliferation', 'display_name': 'Inhibition of oridonin in HepG-2 cells proliferation', 'publication_year': 2014, 'publication_date': '2014-01-01', 'ids': {'openalex': 'https://openalex.org/W2358324654', 'mag': '2358324654'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'http://en.cnki.com.cn/Article_en/CJFDTOTAL-GDYX201402029.htm', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764485101', 'display_name': 'Journal of Guangdong Pharmaceutical University', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': [], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5100401013', 'display_name': 'Hu Wang', 'orcid': 'https://orcid.org/0000-0001-6132-8788'}, 'institutions': [{'id': 'https://openalex.org/I190242452', 'display_name': 'Guangdong Pharmaceutical University', 'ror': 'https://ror.org/02vg7mz57', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I190242452']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Wang Hu', 'raw_affiliation_strings': ['Guangdong Province Key Laboratory of Biotechnology Drug Candidates,School of Biosciences and Biopharmaceutics,Guangdong Pharmaceutical University'], 'affiliations': [{'raw_affiliation_string': 'Guangdong Province Key Laboratory of Biotechnology Drug Candidates,School of Biosciences and Biopharmaceutics,Guangdong Pharmaceutical University', 'institution_ids': ['https://openalex.org/I190242452']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5100401013'], 'corresponding_institution_ids': ['https://openalex.org/I190242452'], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 66}, 'biblio': {'volume': None, 'issue': None, 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12530', 'display_name': 'Bioactive Natural Diterpenoids Research', 'score': 0.9948, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12530', 'display_name': 'Bioactive Natural Diterpenoids Research', 'score': 0.9948, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13095', 'display_name': 'Plant-based Medicinal Research', 'score': 0.9629, 'subfield': {'id': 'https://openalex.org/subfields/3004', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/30', 'display_name': 'Pharmacology, Toxicology and Pharmaceutics'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10211', 'display_name': 'Computational Drug Discovery Methods', 'score': 0.9128, 'subfield': {'id': 'https://openalex.org/subfields/1703', 'display_name': 'Computational Theory and Mathematics'}, 'field': {'id': 'https://openalex.org/fields/17', 'display_name': 'Computer Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/mtt-assay', 'display_name': 'MTT assay', 'score': 0.5946756}, {'id': 'https://openalex.org/keywords/viability-assay', 'display_name': 'Viability assay', 'score': 0.5667926}], 'concepts': [{'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.8273338}, {'id': 'https://openalex.org/C553184892', 'wikidata': 'https://www.wikidata.org/wiki/Q1141429', 'display_name': 'Flow cytometry', 'level': 2, 'score': 0.8139018}, {'id': 'https://openalex.org/C88634738', 'wikidata': 'https://www.wikidata.org/wiki/Q24769543', 'display_name': 'Annexin', 'level': 3, 'score': 0.7736889}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.6763398}, {'id': 'https://openalex.org/C2780783641', 'wikidata': 'https://www.wikidata.org/wiki/Q738686', 'display_name': 'MTT assay', 'level': 3, 'score': 0.5946756}, {'id': 'https://openalex.org/C53227056', 'wikidata': 'https://www.wikidata.org/wiki/Q189152', 'display_name': 'Viability assay', 'level': 3, 'score': 0.5667926}, {'id': 'https://openalex.org/C51551487', 'wikidata': 'https://www.wikidata.org/wiki/Q2043632', 'display_name': 'p38 mitogen-activated protein kinases', 'level': 4, 'score': 0.511596}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.5105906}, {'id': 'https://openalex.org/C169274487', 'wikidata': 'https://www.wikidata.org/wiki/Q840211', 'display_name': 'Fluorescence microscope', 'level': 3, 'score': 0.5083203}, {'id': 'https://openalex.org/C57074206', 'wikidata': 'https://www.wikidata.org/wiki/Q14197552', 'display_name': 'MAPK/ERK pathway', 'level': 3, 'score': 0.44507065}, {'id': 'https://openalex.org/C98424977', 'wikidata': 'https://www.wikidata.org/wiki/Q25805', 'display_name': 'Caspase', 'level': 4, 'score': 0.44103602}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.4360645}, {'id': 'https://openalex.org/C62112901', 'wikidata': 'https://www.wikidata.org/wiki/Q189159', 'display_name': 'Cell growth', 'level': 2, 'score': 0.43133363}, {'id': 'https://openalex.org/C12519072', 'wikidata': 'https://www.wikidata.org/wiki/Q14914370', 'display_name': 'Caspase 3', 'level': 4, 'score': 0.42013022}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.33820522}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.30901945}, {'id': 'https://openalex.org/C31573885', 'wikidata': 'https://www.wikidata.org/wiki/Q304484', 'display_name': 'Programmed cell death', 'level': 3, 'score': 0.19995788}, {'id': 'https://openalex.org/C91881484', 'wikidata': 'https://www.wikidata.org/wiki/Q191807', 'display_name': 'Fluorescence', 'level': 2, 'score': 0.17227465}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.17108741}, {'id': 'https://openalex.org/C121332964', 'wikidata': 'https://www.wikidata.org/wiki/Q413', 'display_name': 'Physics', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C62520636', 'wikidata': 'https://www.wikidata.org/wiki/Q944', 'display_name': 'Quantum mechanics', 'level': 1, 'score': 0.0}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'http://en.cnki.com.cn/Article_en/CJFDTOTAL-GDYX201402029.htm', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764485101', 'display_name': 'Journal of Guangdong Pharmaceutical University', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.56, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W3032625703', 'https://openalex.org/W3025269802', 'https://openalex.org/W2900892049', 'https://openalex.org/W2586697952', 'https://openalex.org/W2394683061', 'https://openalex.org/W2384173773', 'https://openalex.org/W2382296286', 'https://openalex.org/W2380346092', 'https://openalex.org/W2372638622', 'https://openalex.org/W2365451284', 'https://openalex.org/W2365237439', 'https://openalex.org/W2363760585', 'https://openalex.org/W2356678743', 'https://openalex.org/W2353017521', 'https://openalex.org/W2349908224', 'https://openalex.org/W2261279760', 'https://openalex.org/W2236481952', 'https://openalex.org/W2084369506', 'https://openalex.org/W2027827381', 'https://openalex.org/W1876092275'], 'abstract_inverted_index': {'Objective': [0], 'To': [1], 'investigate': [2], 'the': [3, 7, 23, 132, 140, 148], 'proapoptotic': [4], 'effect': [5], 'and': [6, 37, 92, 108, 121, 130], 'underlying': [8], 'mechanism': [9], 'of': [10, 45, 70, 100, 128, 134, 142, 150], 'oridonin': [11, 58, 95, 124], 'in': [12, 63, 67, 73], 'human': [13], 'hepatocarcinoma(HepG-2)': [14], 'cells.': [15], 'Methods': [16], 'MTT': [17], 'assay': [18], 'was': [19, 27, 50], 'used': [20], 'to': [21], 'measure': [22], 'cell': [24, 68], 'viability.': [25], 'Apoptosis': [26], 'determined': [28, 51, 80], 'by': [29, 52, 104], 'flow': [30, 105], 'cytometry': [31, 106], 'analysis': [32, 107], 'after': [33, 40], 'Annexin': [34], 'V/PI': [35], 'staining': [36], 'fluorescence': [38, 116], 'microscope': [39], 'Hoechst': [41], 'staining.': [42], 'The': [43, 77], 'expression': [44, 127, 133], 'MAPK': [46, 154], 'signaling': [47], 'pathway': [48], 'proteins': [49], 'immunoblot': [53], 'analysis.': [54], 'Results': [55], 'Treatment': [56, 118], 'with': [57, 90, 115, 119], 'for': [59, 85, 96], '24': [60, 86, 97], 'h': [61], 'resulted': [62], 'a': [64, 74], 'marked': [65], 'decrease': [66], 'viability': [69], 'HepG-2': [71, 101, 151], 'cells': [72, 102, 152], 'dosedependent': [75], 'manner.': [76], 'IC50values': [78], 'were': [79, 113], 'as': [81, 136, 138], '38.': [82], '41': [83], 'μmol/L': [84, 94, 123], 'h.': [87], 'After': [88], 'treatment': [89], '20,40': [91, 120], '60': [93, 122], 'h,apoptotic': [98], 'rates': [99], 'increased': [103, 131], 'typical': [109], 'apoptotic': [110], 'nucleus': [111], 'alterations': [112], 'observed': [114], 'microscope.': [117], 'down-regulated': [125], 'protein': [126], 'Bcl-2,caspase-9,caspase-3': [129], 'pJNK,p-p38,p-p53': [135], 'well': [137], 'activated': [139], 'cleavage': [141], 'caspase-9.': [143], 'Conclusion': [144], 'Oridonin': [145], 'may': [146], 'induce': [147], 'apoptosis': [149], 'through': [153], 'pathway.': [155]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2358324654', 'counts_by_year': [], 'updated_date': '2024-12-13T05:32:30.465836', 'created_date': '2016-06-24'}