Title: Observation on curative effect of quadruple therapy in Helicobacter pylori-positive gastric ulcer
Abstract: Objective:To observe the clinical effect of esomeprazole combined with rebamipide,amoxicillin and clarithromycin on positive pylorus spirillum gastric ulcer.Methods:60 patients with Helicobacter pylori-positive gastric ulcer were divided randomly into control group(30 cases) and treatment group(30 cases).In the control group,patients were treated with omeprazole,amoxicillin and clar-ithromycin.The treatment group was treated with esomeprazole,rebamipide,amoxicillin and clarithromycin.The change of symptoms,clinical remission rate,ulcer healing rate,Hp eradication rate and ulcer recurrence rate were analyzed between the two groups.Results:①After treatment,the clinical symptom score of abdominal pain,epigastric distention,sour regurgitation and belching significantly de-creased in all patients,especially in treatment group(P0.01 or 0.05).② The cure rate and total effective rate were 60.00% and 93.33% respectively in treatment group,which were significantly higher than 43.33% and 80.00% in the control group(P0.05).③ The stage S2 achievement rate,ulcer healing rate and eradication rate of HP were 93.33%,96.67% and 93.33% in treatment group,which were respec-tively 60.00%,70.00% and 83.33% in control group,and there was significant difference between the two groups(P0.01 or 0.05).④ At the end of 1 year follow-up,the ulcer recurrence rate were 11.54% and 32.00% in treatment and control group respectively,and there was significant difference between the two groups(P0.05).Conclusion:Quadruple therapy of Hp-positive gastric ulcer could relieve the clin-ical symptom of patients,improve the quality of ulcer healing,eradicate Hp,and prevent reoccurrence,which is better than triple therapy.
Publication Year: 2011
Publication Date: 2011-01-01
Language: en
Type: article
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