Title: The treatment of allograft rejection after corneal transplantation.
Abstract: Objective To develop an effective approach to control and treat allograft rejection after corneal transplantation. Methods According to the different preexisting diseases of the recipient corneas, immunosuppre-ssive drugs were administered simply or in combination. Results 47 out of 129 eyes experienced allograft rejection. The rejection rate in high risk patients was 85.11 % (40/47) , in low risk eyes was 14. 8 % (7/47) . In the vascularized corneas,it was 89.36%(42/47) .The incipient of rejection varied from 3 weeks to 3 years after corneal transplantation. The crucial episodes were 3-6 months after corneal transplantation. In this period, the total rejection rate was 46.81% .After immunosuppressive drugs were administered, 63. 83 % percent allograft rejection was effectively blocked. Conclusion Many factors contribute to the complicated allograft rejection of corneal transplantation. In vascularized, inflamed, regraft corneas,the allograft rejection occur more often,more early,and more severe and last for a longer time. So in such cases, immunosuppressive drugs should be prophylactically administered in combination and may help reverse an ongoing graft-rejection episode.
Publication Year: 2003
Publication Date: 2003-01-01
Language: en
Type: article
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