Title: The effect of ziyinmingmuwan(滋阴明目丸)on expression of p53 and Bcl-2 in rat retinal with retinal photic injury
Abstract: OBJECTIVE To investigate the protective effect and mechanism of ziyinmingmuwan(滋阴明目丸)on retina against photic injury.METHODS Seventy Sprague-Dawley(SD)rats were randomly divided into 7 groups,with 6 groups prepared as the models of photic trauma at first and another group taken as blank controlling one among these groups.After three days,the animals in the treatment and controlling groups were treated with ziyinmingmuwan and control agent respectively for 15 days during the period of experiment.following this,the retinal tissues were taken to test the expressive activities of p53 and Bcl-2 genes by immunohistochemical method.RESULTS Compared with the model group,the expression of p53 was decreased and Bcl-2 was increased evidently in groups of ziyinmingmuwan,which showed significant difference(P0.01).CONCLUSIONS Ziyinmingmuwan could inhibit the expression of p53 gene and enhance the expression of bcl-2 gene to induce an inhibitory effect on apoptosis of the retinal cells.
Publication Year: 2006
Publication Date: 2006-01-01
Language: en
Type: article
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