Title: Long-term exposure to low level of lead on cellular immune function in mice
Abstract: Objective:To observe the effect of long term exposure to low level of lead on cellular immune function in mice.Methods:One hundred and twenty mice were randomly divided into 6 groups;of them,one group were reared on normal feed,while the remaining 5 groups were fed with lead of different strengths.Serum level of lead and tumor necrosis factor(TNF) α,T lymphocyte subsets and spleen index were measured after 8 weeks of treatment.Results:Serum lead level gained with the increase of exposure dosage of lead;whereas the number of CD + 4 cells,the ratio of CD + 4/CD + 8 and serum TNE α concentration decreased with the growth of serum level of lead.There was an obvious difference in spleen index between control group and treatment group.Conclusion:It is suggested that long term lead exposure,even at a relatively low level could impair the cell mediated immunity and immune organ.
Publication Year: 2002
Publication Date: 2002-01-01
Language: en
Type: article
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