Title: Experimental studies on antiproliferation activities and early apoptosis inducement of polysaccharides from Spirulina platensis
Abstract:In vitro experiments the antiproliferation activities of polysaccharides from Spirulina platensis(PSP) were evaluated on Hela cells and HepG2 cells by MTT assay,the results showed that PSP(2.5~40 mg/L...In vitro experiments the antiproliferation activities of polysaccharides from Spirulina platensis(PSP) were evaluated on Hela cells and HepG2 cells by MTT assay,the results showed that PSP(2.5~40 mg/L,48~72 h) exhibited dose and time inhibition effects on the cell growth.The early apoptosis of Hela cells was detected by flow cytometry analysis with a combination of Annexin V-FITC and PI double staining,the apoptosis rates induced by PSP(5,10,20,40 mg/L) were 30.3%,32.6%,34.8% and 38.8% respectively,which were higher than those of the normal control group(P0.05).Meanwhile,the apoptosis rate treated by PSP(40 mg/L) also increased in time-dependent manner.These results suggested that one of the anti-tumor mechanisms of PSP may be related to inhibition on cell proliferation and induction of notable apoptosis.Read More
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
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Cited By Count: 2
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