Title: Comparison of therapeutic effects between insulin pump,insulin aspart 30 and insulin glargine combined with repaglinide in treating hyperglycemia
Abstract: Objective To study the therapeutic effects of insulin pump,insulin aspart 30 and insulin glargine combined with repaglinide in treating hyperglycemia.Methods 179 patients with type 2 diabetes mellitus with poor blood glucose control were grouped by insulin pump for two weeks followed by insulin aspart 30(n=57),insulin aspart 30(n=63),and insulin glargine combined with repaglinide for sixmonths(n=59).The blood glucose,glycosylated hemoglobin and fructosamine before and after treatment were observed.Results(1)There were statistically significant differences in blood glucose at various points in 24 hours between the three groups(P0.001).After treatment there were no significant differences at other points but higher blood glucose at three o'clock in insulin glargine combined with repaglinide group than in other two groups(P0.05).(2)There were statistically significant differences in glycosylated hemoglobin between insulin aspart 30 and insulin glargine combined with repaglinide group before and after treatment(P0.001),but after treatment there was no significant difference between the two groups.(3)Therewere statistically significant differences in serious and slight symptomatic hypoglycemia between the three groups(P0.001).Conclusions All the above three treatments can reduce the blood glucose,glycosylated hemoglobin or fructosamine satisfactorily.The maximum hypoglycemia rate occurs in insulin pump group and minimum hypoglycemia rate in insulin glargine group.
Publication Year: 2009
Publication Date: 2009-01-01
Language: en
Type: article
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