Title: Efficacy of Mirtazapine and Sertraline in the Treatment of Depression with Anxiety Symptoms
Abstract:Objective:To compare the clinical effects and adverse reactions of mirtazapine and sertraline in the treatment of depression associated with anxiety. Methods:One hundred and eleven patients depression...Objective:To compare the clinical effects and adverse reactions of mirtazapine and sertraline in the treatment of depression associated with anxiety. Methods:One hundred and eleven patients depression associated with anxiety were divided into 2 groups: Fifty-six patients (M30, F26, age 39.4±13.7) were treated with mirtazapine, 30~45mg, po, qd for 6wk;; fifty-five patients (M29, F26, age 40.2±12.6) were treated with sertraline, 50~100mg, po, qd for 6wk. Results:The marked effective rate of mirtazapine group and sertraline group were 73.2% and 67.3% (P0.05) in treating depression symptoms, but the marked effective rate of mirtazapine group and sertraline group were 78.8% and 43.6% (P0.05) in treating anxiety symptoms. The adverse reactions in mirtazapine group and sertraline group should no significant difference. Conclusion:Mirtazapine and sertraline is a safe and effective drug for treatment of depression, but mirtazapine is superior to sertraline in reducing anxiety symptoms.Read More
Publication Year: 2004
Publication Date: 2004-01-01
Language: en
Type: article
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Cited By Count: 2
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Title: $Efficacy of Mirtazapine and Sertraline in the Treatment of Depression with Anxiety Symptoms
Abstract: Objective:To compare the clinical effects and adverse reactions of mirtazapine and sertraline in the treatment of depression associated with anxiety. Methods:One hundred and eleven patients depression associated with anxiety were divided into 2 groups: Fifty-six patients (M30, F26, age 39.4±13.7) were treated with mirtazapine, 30~45mg, po, qd for 6wk;; fifty-five patients (M29, F26, age 40.2±12.6) were treated with sertraline, 50~100mg, po, qd for 6wk. Results:The marked effective rate of mirtazapine group and sertraline group were 73.2% and 67.3% (P0.05) in treating depression symptoms, but the marked effective rate of mirtazapine group and sertraline group were 78.8% and 43.6% (P0.05) in treating anxiety symptoms. The adverse reactions in mirtazapine group and sertraline group should no significant difference. Conclusion:Mirtazapine and sertraline is a safe and effective drug for treatment of depression, but mirtazapine is superior to sertraline in reducing anxiety symptoms.