Title: Effects of Dexmedetomidine Combined with Propofol on Hemodynamics in Patients Undergoing General Anesthesia
Abstract: OBJECTIVE:To observe the effects of dexmedetomidine combined with propofol on hemodynamics in patients undergoing general anesthesia. METHODS:60 patients undergoing elective general anesthesia surgery were divided into 5 groups by according to random number table method:Sodium chloride injection group(group C),dexmedetomidine groups(D1-D4 groups). All patients were given anesthesia induction of propofol. Group C was given Sodium chloride injection,D1-D4 groups were given dexmedetomidine. HR and MAP of 5 groups were monitored at pre-induction(T0),5 min(T1)and 10 min(T2)after treatment, eyelash reflex disappearing(T3),loss of consciousness(T4),laryngoscope(T5),1 min(T6)and 3 min(T7)after intubation. The concentrations of propofol effect chamber(ECC)and dose were recorded at T3 and T4. Positive reaction and adverse drug reactions of endotracheal intubation were recorded. RESULTS:Compared with T0,HR and MAP in group C and D1 at T5 and T6 increased significantly;there was statistical significance(P0.05);Compared with T0,HR and MAP of group D2 and D3 were decreased at T1-T4;there was statistical significance(P0.05);compared with T0,HR of group D4 were decreased significantly at various time points;MAP of group D4 were increased significantly at T1 and T2;there was statistical significance(P0.05). Compared with group C and D1,HR in group D2,D3 and D4 at T2 to T6 were decreased significantly;MAP in group D2 and D3 at T3 to T6 decreased significantly;there was statistical significance(P0.05);the concentration of ECC and dose in group D2,D3 and D4 at T3 to T4 were significantly decreased;and those of group D3 and D4 were lower than group D2;there was statistical significance(P 0.05). In group D2 and D3,the incidence of ADR was significantly lower than that of group C,D1 and D4;that of group D2 was significantly lower than group D3;there was statistical significance(P0.05). CONCLUSIONS:Dexmedetomidine combined with propofol used in surgery patients undergoing general anesthesia not only keep hemodynamics stable during induction of general anesthesia,but also effectively control stress reaction. But the curative efficacy and safety of dexmedetomidine used in elderly patients during anesthesia induction has yet to be further studied.
Publication Year: 2014
Publication Date: 2014-01-01
Language: en
Type: article
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