Title: The changes of substance P in induced sputum in asthmastic children
Abstract:Objective To investigate the changes and clinical significance of substance P (SP) concentration in induced sputum in children with bronchial asthma.Methods Collected sputum in children with bronchial...Objective To investigate the changes and clinical significance of substance P (SP) concentration in induced sputum in children with bronchial asthma.Methods Collected sputum in children with bronchial asthma and normal volunteers by way of hypertonic saline inhalation challenge.34 patients were in the acute episode and 30 in remission;22 volunteers were detected as normal control.SP concentration in induced sputum was measured by radioimmunoassy.Results The SP concentration in induced sputum was significantly higher in the acute episode group in asthmatic children than that in remission period group (P0.01) and in normal control (P0.01);there was no significantly difference between in remission period and in normal control (P0.05).Conclusion The SP concentration in induced sputum was significantly higher at the stage of acute episode in asthmatic children than both in the remission period and in normal volunteers.The results suggested that SP concentration in induced sputum has close relationship with asthma in children..Read More
Publication Year: 2004
Publication Date: 2004-01-01
Language: en
Type: article
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