Title: Clinical significance of plasma total bile acid and gamma globulin in patients with hepatic cirrhosis
Abstract: Objective: To study the levels of plasma total bile acid(TBA) and gamma globulin and to assess their clinical significance. Methods: The plasma levels of TBA and gamma globulin were measured in 49 patients with hepatic cirrhosis and 34 patients with non-hepatic diseases. At the same time, the other indexes of liver function were also detected including serum total bilirubin (TBiL) , albumin (ALB), aspartate aminotransferase(SGPT), alanine aminotransferase(SGOT), gamma glutamyl transpeptidase (γ-GT) and alkaline phosphate (AKP). Results: The levels of plasma TBA and gamma globulin were significantly higher in patients with hepatic cirrhosis than those with non-hepatic diseases (P0.01). According to the Child-Pugh classification,the level of plasma TBA was the highest in Child-Pugh C grade and was significantly different between Child-Pugh C grade and Child-Pugh A grade as well as Child-Pugh B grade (P0.05).The higher the liver function of Child-Pugh grade, the higher the gamma globulin rise (P0.01). In comparison with the other liver function tests, the sensitivity of TBA was better than TBiL, γ-GT and AKP (P0.05) and the sensitivity of gamma globulin was better than ALB (P 0.01). Conclusion: The levels of plasma TBA and gamma globulin are closely associated with the severity of hepatic cirrhosis and are helpful for confirming state of the illness and reflecting prognosis.
Publication Year: 2002
Publication Date: 2002-01-01
Language: en
Type: article
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