Title: The expression of P-glycoprotein in breast carcinoma
Abstract: Objective To study P-glycoprotein(P-gp),the mdr-1 gene product,expression and response to pirarubicin containing regimen in recurrent and metastatic breast carcinoma.Methods P-gp expression in 40 postoperative patients with recurrent and metastatic breast carcinoma was detected by SABC immunohistochemical method.The patients were treated with combination regimen of cyclophosphamide,pirarubicin and 5-fluorouracil.The correlation between P-gp expression and chemotherapeutic response was analyzed.Results The positive rate of P-gp expression in patients with lung or liver metastasis was higher than that in skin or lymphnode metastasis(P=0.049);The overall response rate was 52.5% in 40 patients;The responserate 84.2% of the P-gp negative group was higher than that 33.3% of the P-gp positive group(P0.01).The response rate(78.5%) in the patients with skin or lymphnode metastasis was higher than that(32.5%) of the patients with lung or liver metastasis(P0.05).In the post operative patients who had received CAF or CMF regimen adjuvant chemotherapy previously,the response rate of metastatic diseases to chemotherapy had significant difference 33.3% and 73.6%,respectively(P0.05).Conclusion Patients with P-gp positivere current and metastatic breast carcinoma should be treated with chemotheraphy combined with non-MDR drug.
Publication Year: 2006
Publication Date: 2006-01-01
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot