Title: The Clinical Observation of Oxaliplatin in Combination with Capecitabine in Patients with Advanced Gastric Cancer
Abstract: Objective To evaluate the efficacy and safety of Oxaliplatin in combination with capecitabine in treating advanced gastric cancer.Methods Thirty-five patients with advanced gastric cancer received chemotherapy: Oxaliplatin 100 mg/m~2 i.v,d1; combining oral capecitabine 2000mg/m~2.d (divided in two doses) d1-14; and repeated every 3 weeks.The efficacy and safety were assessed in every cycle.Results 2 cases (5.71%) achieved CR,13 cases (37.14%) had PR,10 cases (8.57%) had SD,10 cases (28.57%) had PD,with an overall response rate of 42.86%.The most common adverse effects were leucopenia,hand-foot syndrome,diarrhea and skin pigmentation.There was no treatment-related death.Conclusion Chemotherapy with oxaliplatin combined with capecitabine is effective and well-tolerated to the patients with advanced gastric cancer.
Publication Year: 2007
Publication Date: 2007-01-01
Language: en
Type: article
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