Title: Evaluation by high-resolution ultrasonography of endothelial function in brachial artery after Kawasaki disease and the effects of intravenous administration of vitamin C
Abstract: ObjectiveHigh-resolution ultrasonography was used to analyze brachial artery responses to reactive hyperemia (with increased flow causing endothelial-dependent dilation) and sublingual nitroglycerin (causing endothelial-independent dilation) after Kawasaki disease (KD),to investigate whether the acute administration of vitamin C can restore systemic endothelial dysfunction.MethodsThe endothelia-dependent and -independent vasodilation of the brachial artery was evaluated in 39 patients after KD for the brachial vasodilation before and after vitamin C or placebo infusion intravenously.ResultsIntravenous infusion of vitamin C significantly increased the percent change in diameter of the brachial artery induced by reactive hyperemia in 19 patients with history of KD [( 6.6 ± 3.5 )% to ( 13.0 ± 5.5 )%,P 0.0001 ].After placebo administration in 20 patients with history of KD there was no significant increase in the percent change in the diameter of the brachial artery induced by reactive hyperemia [( 6.5 ± 4.5 )% to ( 7.3 ± 4.9 )%,P=0.20].ConclusionsSystemic vascular endothelial function after KD can be restored by acute intravenous administration of vitamin C.
Publication Year: 2004
Publication Date: 2004-01-01
Language: en
Type: article
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