Title: Effects of aspirin on the expression of transforming growth factorβ1 in the kidney of diabetic rats
Abstract:Objective To study the protective effects of aspirin on renal lesions in diabetic rats.Methods The model of diabetic rats was induced by streptozotocin.The diabetic rats were treated with 10 mg·kg~(-1...Objective To study the protective effects of aspirin on renal lesions in diabetic rats.Methods The model of diabetic rats was induced by streptozotocin.The diabetic rats were treated with 10 mg·kg~(-1)·d~(-1) aspirin for 6 weeks.The urinary albumin excretion and creatinine clearance(Ccr) were tested.The expression of TGF-β1 in renal cortex of diabetic rats was determined by immunohistochemical staining.Results The Ccr was decreased in diabetic rats with the treatment of aspirin for 6 weeks and the urinary albumin excretion was not obviously decreased.The immunohistochemical staining of TGF-β1 in aspirin-treated group was significantly decreased than that of the control group(P0.05).Conclusion The aspirin inhibits the overexpression of TGF-β1,which is involved in the protection of kidney in diabetic rats.Read More
Publication Year: 2006
Publication Date: 2006-01-01
Language: en
Type: article
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