Title: Penumbra assessment of acute cerebral ischemic in rats by CT perfusion
Abstract: Objective To investigate viability thresholds of penumbra by CT perfusion in acute cerebral ischemia. Methods Acute cerebral ischemic models were presented in 54 Wistar rats by obstructing the unilateral middle cerebral artery. Dynamic scans with venous bolus injection of contrast media were performed at 3, 4, 6, 8 h respectively after operation in ischemic group with SIEMENS Somatom Sensation 16-slice CT. In reperfusion group, dynamic scans with venous bolus injection of contrast media were performed at 3, 4, 6, 8 h respectively before and after reperfusion. The relative cerebral blood flow (rCBF) of region of interest was measured and calculated. After every intervals of CT scan, cerebral tissues were observed by photomicroscope and electron microscope. Results The techniques of CT perfusion, not only located the ischemic focus during the acute phase, but also quantitatively evaluated the abnormal hemodynamics in the pre-infarction periods and differentiate cerebral infarction from ischemia. If cerebral ischemic models after operation were in 4 h, there were still penumbra areas even if that of rCBF was 0.146, viability threshold of penumbra after 6 h was 0.212. After ischemic 6 h, infracted areas and cell karyopycnosis could be found by photomicroscope and electron microscope. Conclusion CT perfusion imaging could assess the viability thresholds of penumbra in acute cerebral ischemia.
Publication Year: 2007
Publication Date: 2007-01-01
Language: en
Type: article
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