Title: Synthesis of 2-hydroxy-5,7-dimethyl-1,2,4-triazolopyrimidine
Abstract:The 2-hydroxyl-5,7-dimethyl-1,2,4-triazolopyrimidine(TPO) is an important intermediate for triazolopyrimidine derivatives.It was synthesized from amidourea hydrochloride by way of ring closure,nitrati...The 2-hydroxyl-5,7-dimethyl-1,2,4-triazolopyrimidine(TPO) is an important intermediate for triazolopyrimidine derivatives.It was synthesized from amidourea hydrochloride by way of ring closure,nitration,deoxidization and cyclization.First,amidourea hydrochloride reacted with formyl acid to form 1,2,4-triazol-5-one(TO) with a yield of 86.5%.Second,the TO was nitrated using fuming nitric acid to prepare the 3-nitro-1,2,4-triazol-5-one(NTO) with a yield of 90.1%.Third,NTO was reduced by using H_2 in the presence of Raney Ni to obtain the 3-amino-5-hydroxyl-1,2,4-triazole(ATO) with a yield of 88.0%.The TPO was then synthesized from ATO together with acetyl acetone with a yield of 86.0%.The overall yield was 59.0%.The synthesis route used is simple.The reaction conditions are mild.And the raw materials are cheap and easy to obtain.Read More
Publication Year: 2007
Publication Date: 2007-01-01
Language: en
Type: article
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