Title: Effect of total flavone of Abelmoschus manihot(L.) Medic. on angiogenesis in human umbilical endothelial cells
Abstract:Objective To investigate the proangiogenic effects of total flavone of Abelmoschus manihot(L.) Medic.(TFA) in human umbilical vein endothelial cells(HUVEC).Methods The HUVEC cultured in vitro served a...Objective To investigate the proangiogenic effects of total flavone of Abelmoschus manihot(L.) Medic.(TFA) in human umbilical vein endothelial cells(HUVEC).Methods The HUVEC cultured in vitro served as the model to determine the cell proliferation with MTT.The effect of TFA on HUVEC migration was detected by Transwell chamber migration assay,and cell differentiation was examined by endothelial tube formation assay.Results Treatment with 5-20 μg/ml TFA for 72 h had a marked effect on the proliferation of HUVECs,and strongly promoted the migration,10-20 μg/ml TFA could promote tube formation of HUVEC.Conclusion TFA at certain concentrations exerts a potent proangiogenic effect on HUVEC in vitro.Read More
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot