Title: The expression of mTOR in esophageal squamous cell carcinoma tissues and peripheral T lymphocytes
Abstract: To evaluate the expression of mTOR and its signal pathway in esophageal squamous cell carcinoma tissues and peripheral T lymphocytes,40 cases of esophageal squamous cell carcinoma tissues,tumor-adjacent tissues and peripheral T lymphocytes were collected.Immunohistochemistry,real-time PCR and FACS were employed to detect the expression levels of mTOR,raptor and p-TSC2.Results showed that the expressions of mTOR and raptor in esophageal squamous cell carcinoma tissues were significantly higher than those in tumoradjacent tissues,and the positive expression rate of mTOR in Ⅲ-Ⅳ phase patient were significantly higher than that inⅠ-Ⅱ phase patient.Furthermore,the expressions of p-mTOR and p-TSC2 in peripheral T lymphocytes of patients were significantly higher than those in health.In conclusion,the signal pathway of mTOR is much activated in esophageal squamous cell carcinoma tissues and peripheral T lymphocytes.
Publication Year: 2014
Publication Date: 2014-01-01
Language: en
Type: article
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