Title: Study on the relation between neuron loss in hippocampus and cortex and pathogenesis of vascular dementia
Abstract: Objective To probe into the roles of neuron loss in hippocampus and cortex of temporal and frontal lobe in pathogenesis of vascular dementia after cerebral ischemia/ reperfusion repeatedly. Methods Modified Pulsinelli 4 vessel occlusion (4VO) was adopted as a rat model of vascular dementia. Computer controlled initiative avoidance response shuttle box system was used to test the learning and memory capacity of rats. Toluidine blue stained was used to number the remained neural cells in hippocampus and cortex of temporal and frontal lobe. Results Loss rate of pyramidal cells in hippocampus CA1 region came to a stable state in 4VO 4w group and no significant difference was found compared with 4VO 2m group(P0.05). Loss rate of neural cells in hippocampus CA3 region and dentate gyrus came to stable state in 4VO 2w group, but cortex of temporal and frontal lobe in 4VO 1w group. There was an obviously negative correlation between AAR ratio of the tested rats and loss rate of pyramidal cells in CA1 region. A negative correlation exists between AAR ratio of the rats and loss rate of neural cells in CA3 region and dentate gyrus. Otherwise there was no significant correlation between AAR ratio and loss rate of cortex of temporal and frontal lobe. Conclusion The loss of neural cells in hippocampus and cortex of temporal and frontal lobe is an important pathological mechanism of the formation of vascular dementia, but the loss of pyramidal cells in hippocampus CA1 region is the most important.
Publication Year: 2002
Publication Date: 2002-01-01
Language: en
Type: article
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