Title: Review on studies of levonorgestrel-releasing IUD(20 μg)[STBZ]
Abstract: Objective: To review the studies of levonorgestrel-releasing intrauterine devices (LNG-IUD 20 μg/day, Leiras) in our institute to understand its mechanism and long-term contraceptive efficacy and safety.Method: The data from 22 of our related published papers were summerized. Result: After insertion of LNG-IUD for 8 years, only 1 pregnancy occurred in 100 women. The continuation rate was 52% and the medical removal rate was 32.2%. Ten women were followed-up for 1 year and 44.8% showed ovarian cycle. 78.5% of 14 women with the IUD for 6 years had the luteal function. Serum LNG low levels were shown in the women with ovarian function. It indicated that high LNG levels in the endometrium induced amenorrhea. Morphometric study of the endometrium revealed the suppression of endometrial proliferative activity. A significant decrease of endometrial DNA content, the inhibition of ER and PR expression in endometrial cells were also observed. The synthesis and release of endometrial endothelial factor VIII might be inhibited after insertion. These studies also indicated the mechanism of action is mostly on the endometrium. Thirty-four patients with idiopathic menorrhagia were treated by LNG-IUD insertion for 3 years. After insertion of LNG-IUD, menstrual blood loss became markedly reduced, hemoglobin and serum ferritin levels were significant increased. Conclusion: LNG-IUD (20 μg) is a highly effective, long term safe and reversible contraceptive method. The main advantage is the decrease of MBL. It is highly accepted by our women, particularly for those with menorrhagia and anemia.
Publication Year: 2005
Publication Date: 2005-01-01
Language: en
Type: article
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