Title: Clinical Observation of Effect of Zhengbiguanjie Tablet Combined Methotrexate with Treating Active Rheumatoid Arthritis
Abstract: Objective To observe the efficacy and safety of Zhengbiguanjie tablet combined with Methotrexate(MTX) in active rheumatoid arthritis(RA).Methods Forty-eight active rheumatoid arthritis patients were randomized into 2 groups with a ratio of 2∶ 1;32 patients in the treatment group were treated with Zhengbiguanjie tablet plus MTX,while 16 patients in the control group were administered with simulant of Zhengbiguanjie tablet plus MTX;the therapeutic course for both groups was 12 weeks.The efficacy,clinical symptoms,sighs and changes in biochemical examination results of the respective groups were observed for comparison.Results Compared to the control group,the clinical symptoms and signs were relieved earlier in the treatment group with biochemical examination results showing positive response to treatment.The total effective rate was 82.1%,89.3%,92.9% in the treatment group,and 53.8%,61.5%,84.6% in the control group at 4,8 and 12 weeks after treatment respectively.Comparing the therapeutic effect between the two groups showed significant difference(P0.05).Conclusion Zhengbiguanjie tablet plus MTX treatment is characterized by quick initiating,with stable clinical efficacy and few side effects.It is better than MTX treatment alone.
Publication Year: 2012
Publication Date: 2012-01-01
Language: en
Type: article
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