Title: Effects of morphine preconditioning on levels of S-100β protein and neuron-specific enolase in the serum in patients undergoing cardiac operations
Abstract: Objective To observe the changes of levels of S-100β protein and neuron-specific enolase(NSE) in the serum in patients undergoing cardiac surgery by morphine preconditioning from CPB in some degree.Methods Sixteen adult patients were randomly divided into morphine preconditioning group (M group) and control group(C group).After conventional anesthesia induction and tracheal intubation,continuous infusion of propofol and sevoflurane inhalation were used to maintain anesthesia.Additional fentanyl and pipecuronium were intermittently added if they were needed.Morphine preconditioning group was given morphine 0.2 mg/kg after thoracotomy.At the time of after induction (T1),30 min after the CPB (T2),the end of CPB (T3),the end of surgery (T4) and the six hours after surgery (T5),4 ml blood samples were respectively drew from the central line and ELISA assay was used to determine the S-100β protein and NSE levels.Results S-100β protein levels were significantly higher at 30 min after the beginning of the cardiopulmonary bypass (CPB),and the highest level occurred at the end of CPB,then they were gradually decreased in two groups.At the end of CPB,the S-100β protein levels of M group were significantly lower than that of the C group,and the NSE levels of C group significantly increased,but M group had no significant changed.At the end of the surgery,the levels of NSE were higher than that of the time after conduction in the two groups.Conclusions After cardiopulmonary bypass in cardiac surgery,the levels of S-100β protein and NSE were significantly increased,suggesting the possibility of brain damage occurred.S-100β protein level is more sensitive than that of NSE for detecting the brain damage.Morphine preconditioning may significantly reduce the levels of S-100β protein,indicating that morphine preconditioning may protect the brain damage.
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
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