Title: The diagnostic value of hepatic and splenic density for chronic hepatic fibrosis and early cirrhosis
Abstract: Objective:To investigate the feature of hepatic and splenic density change in chronic hepatic fibrosis,and explore its clinical application value.Methods:Plain and tri-stage enhance CT scan of epigast was performed in 84 participants,including 48 patients with hepatic fibrosis which divided into Si(12/48),S2(14/48),S3(9/48)and S4 (13/48)confirmed by liver pathologic biopsy,16 patients with typical cirrhosis,and 20 healthy subjects as control group.Hepatic and splenic density were measured on image of plain scan respectively,density ratios of liver/spleen was calculated in comparison with histopathologic stage.Results:The density of hepatic lobes and total liver trended to decreased at S1-4(S4 was minimun)but increased slightly than S4 at typical cirrhosis.The density of spleen had no significant difference among all groups.The density ratios of liver/spleen at S4 was minimum(1.08±0.07)and had statistical difference with other groups.Conclusion:The measurement of hepatic density and CT value ratios of liver/ spleen may be helpful for the diagnosis of early cirrhosis,but its clinical application value was limited,it's impossible to diagnose hepatic fibrosis or early cirrhosis by measuring the density of liver only.
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
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