Title: Effect of OFR on small intestinal injury in rats exposed to sulfur mustard and burn
Abstract:Objective To investigate the effect of oxygen free radical (OFR) on the injury of small intestine in rats treated with burn, sulfur mustard or sulfur mustard plus burn. Methods Totally 95 SD rats were...Objective To investigate the effect of oxygen free radical (OFR) on the injury of small intestine in rats treated with burn, sulfur mustard or sulfur mustard plus burn. Methods Totally 95 SD rats were randomly divided into four groups: 30 rats subjected to 30 third-degree TBSA scalding (B), 30 injected subcutaneously with 2 ml/kg sulfur mustard (S), 30 subjected to both (SB), 5 as normal controls (C). Activity of diamine oxidase (DAO) and superoxide dismutases (SODs), contents of malonaldehyde (MDA) in plasma, and pathological changes of ileum at 2, 6, 12, 24, 48, 72 h after injury were observed. Results Three treatments could induce significant decrease of activity of SODs (P0.01) and significant increase of DAO activity and MDA contents in plasma (P0.01) , as compared with controls. The lesions of different degree were found in ileal specimens of three treated groups, severer in SB group than the other three groups (P0.01), and there was a direct correlation between injury degree and the time after injury. Conclusion The complex injury of sulfur mustard intoxication and burn may produce more severe lesions in small intestine and high level of oxidative stress in rats than those induced by burn or sulfur mustard alone. OFR may play an important role in the injury due to burn and/or sulfur mustard.Read More
Publication Year: 2006
Publication Date: 2006-01-01
Language: en
Type: article
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