Title: Effect of chrono on median effective dose of convulsion induced by procaine,tetracaine and bupivacaine
Abstract: Objective To observe the effects of chrono on the median effective dose(ED_(50)) of convulsion induced by anaesthetics ( procaine , tetracaine and bupivacaine ). Methods One hundred and eighty mouse were randomly divided into 3 groups which were then divided into four subgroups. Each subgroup had 15 mouse. Procaine,tetracaine and bupivacaine were intraperitoneally injected at 2∶00,8∶00,14∶00 and 20∶00,respectively. The convulsion was investigated and ED_(50) at different times was determined by up-down sequential allocation in mouse. Results The convulsive ED_(50) of procaine at 8∶00 was significantly lower than that at 2∶00,14∶00 and 20∶00(P0.05). The convulsive ED_(50)s of tetracaine and bupivacaine at 14∶00 were significantly lower than that at 2∶00,8∶00 and 20∶00(P0.05).Conclusion The effects of convulsive (ED_(50)s) of procaine, tetracaine and bupivacaine were chrono-dependent.
Publication Year: 2005
Publication Date: 2005-01-01
Language: en
Type: article
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